Pharmacology
Reply the next questions in three well-developed paragraphs utilizing APA formatting, integrating two evidence-based assets to incorporate scientific observe tips in addition to the course textbook.
Overview: Gastrointestinal Case Research
NU641 Advanced Clinical Pharmacology Week 4 Discussion Gastrointestinal Case Study Answer the following questions in three well-developed paragraphs (450–500 words) using APA formatting, integrating two evidence-based resources to include clinical practice guidelines as well as the course textbook. Overview: Gastrointestinal Case Study Joshua George is a 42-year-old white man presenting with a 2-month history of intermittent mid-epigastric pain. The pain sometimes wakes him up at night and seems to get better after he eats a meal. J.G. informs you that his doctor told him that he had an infection in his stomach 6 months ago. He never followed up and has been taking over-the-counter antacids and histamine receptor antagonists (H2Ras) for 2 weeks without relief. He takes no other medications. He is concerned because the pain is continuing. He has no other significant history except he is a 20 pack-year smoker and he drinks 5 cups of coffee a day. He eats late at night and goes to bed about 30 minutes after dinner. He is allergic to penicillin. Diagnosis: Peptic Ulcer Disease List specific goals for treatment for J.G. What drug therapy would you prescribe for J.G.? Please provide your rationales. What are the parameters for monitoring success of the therapy? Discuss specific patient education based on the prescribed therapy. List one or two adverse reactions for the selected agent that would cause you to change therapy. What would be the choice for second-line therapy? What over-the-counter and/or alternative medications would be appropriate for J.G.? What lifestyle changes would you recommend to J.G.? Describe one or two drug–drug or drug–food interaction for the selected agent.
Source: https://www.homeworkjoy.com/questions/regis-nu641-complete-course-latest-2021-september-628259/
© homeworkjoy.comAnalysis: Peptic Ulcer Illness
1. Checklist particular targets for therapy for J.G. (75 phrases)
2. What drug remedy would you prescribe for J.G.? Please present your rationales. (100 phrases)
three. What are the parameters for monitoring success of the remedy? (75 phrases)
four. Talk about particular affected person schooling primarily based on the prescribed remedy. (100 phrases)
5. Checklist one or two antagonistic reactions for the chosen agent that might trigger you to vary remedy (25 phrases)
6. What could be the selection for second-line remedy? (50 phrases)
7. What over-the-counter and/or different drugs could be applicable for J.G.? (25 phrases)
eight. What life-style modifications would you suggest to J.G.? (75 phrases)
9. Describe one or two drug–drug or drug–meals interplay for the chosen agent (50 phrases)
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The main goals for J.G.’s treatment would be to relieve his epigastric pain, heal his peptic ulcer, and prevent future recurrences (Mayo Clinic, 2022). Based on his symptoms and medical history, I would prescribe a proton pump inhibitor (PPI) such as omeprazole. PPIs are first-line therapy for peptic ulcer disease as they are highly effective at reducing gastric acid production and promoting ulcer healing (Fass et al., 2016). Omeprazole has a rapid onset of action within 3-5 days and high healing rates of 80-90% within 4-8 weeks of treatment (National Institute for Health and Care Excellence, 2020).
To monitor the success of omeprazole therapy, I would follow-up with J.G. in 4 weeks to assess resolution of his pain and evaluate for ulcer healing via endoscopy if symptoms persist (Fass et al., 2016). Additional parameters include monitoring for adverse drug reactions and adherence to lifestyle modifications. Common side effects of omeprazole include headache and diarrhea, but are typically mild. If J.G. experienced severe side effects, I would consider changing to another PPI like pantoprazole or rabeprazole (National Institute for Health and Care Excellence, 2020).
Some key patient education points regarding omeprazole include taking it once daily 30 minutes before eating, continuing the full prescribed course even if symptoms improve, avoiding NSAIDs and alcohol, and making dietary changes like eating smaller, more frequent meals (Mayo Clinic, 2022). I would also recommend J.G. quit smoking and limit coffee intake to reduce gastric irritation (Fass et al., 2016). Lifestyle modifications, along with PPI therapy, provide the best approach for managing his peptic ulcer disease long-term.
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Overview
This paper will analyze the gastrointestinal case study of 42-year-old Joshua George presenting with a 2-month history of intermittent mid-epigastric pain. Goals of treatment, drug therapy recommendations, monitoring parameters, patient education points, alternative therapies, lifestyle modifications, and potential drug interactions will be discussed.
Goals of Treatment
The main goals for J.G.’s treatment would be to relieve his epigastric pain, heal his peptic ulcer, and prevent future recurrences (Mayo Clinic, 2022). Relieving his pain is critical to improve his quality of life while healing the ulcer and preventing recurrence aims to manage his condition long-term.
Drug Therapy Recommendations
Based on J.G.’s symptoms and medical history, a proton pump inhibitor (PPI) such as omeprazole is recommended as first-line therapy. PPIs are highly effective at reducing gastric acid production and promoting ulcer healing (Fass et al., 2016). Omeprazole specifically has rapid onset within 3-5 days and high healing rates of 80-90% within 4-8 weeks of treatment (National Institute for Health and Care Excellence, 2020). As the most evidence-based option, omeprazole provides the best chance for resolving J.G.’s pain and healing his ulcer.
Monitoring Parameters
To monitor treatment success, J.G. should follow-up in 4 weeks to assess pain resolution and consider endoscopy if still symptomatic (Fass et al., 2016). Adverse reactions and medication adherence will also be monitored. Common omeprazole side effects are mild but more severe issues could warrant changing to another PPI like pantoprazole or rabeprazole (National Institute for Health and Care Excellence, 2020).
Patient Education
Key points for J.G. include taking omeprazole once daily before eating, continuing the full course, avoiding NSAIDs/alcohol, and making dietary changes like smaller, more frequent meals (Mayo Clinic, 2022). He should also quit smoking and limit coffee intake to reduce gastric irritation (Fass et al., 2016). Complying with lifestyle modifications optimizes omeprazole therapy.
Conclusion
In summary, omeprazole therapy alongside lifestyle changes provides the best approach for managing J.G.’s peptic ulcer disease currently and long-term. Close monitoring will help ensure treatment success.
References
Fass, R., Shapiro, M., Dekel, R., & Fass, G. (2016). Review article: epidemiology, risk factors and pathogenesis of peptic ulcer disease. Alimentary pharmacology & therapeutics homework help writing assignment service, 43 Suppl 1, 3–10. https://doi.org/10.1111/apt.13437
Mayo Clinic. (2022). Peptic ulcer disease – Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/peptic-ulcer/symptoms-causes/syc-20354223
National Institute for Health and Care Excellence. (2020, August). Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. NICE. https://www.nice.org.uk/guidance/ng147
