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Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece.
Review the case study assigned by your Instructor for this Assignment.
Select one the following factors: genetics, gender, ethnicity, age, or behavior factors.
Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes.
Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy.
Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.
References:
Rosenthal, L. D., & Burchum, J. R. (2021). Lehne’s pharmacotherapeutics for advanced practice nurses and physician assistants (2nd ed.) St. Louis, MO: Elsevier.
Chapter 33, “Review of Hemodynamics” (pp. 285–289)
Chapter 37, “Diuretics” (pp. 290–296)
Chapter 38, “Drugs Acting on the Renin-Angiotensin-Aldosterone System” (pp. 297–307)
Chapter 39, “Calcium Channel Blockers” (pp. 308–312)
Chapter 40, “Vasodilators” (pp. 313–317)
Chapter 41, “Drugs for Hypertension” (pp. 316–324)
Chapter 42, “Drugs for Heart Failure” (pp. 325–336)
Chapter 43, “Antidysrhythmic Drugs” (pp. 337–348)
Chapter 44, “Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels” (pp. 349–363)
Chapter 45, “Drugs for Angina Pectoris” (pp. 364–371)
Chapter 46, “Anticoagulant and Antiplatelet Drugs” (pp. 372–388)
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Pharmacotherapeutics for Cardiovascular Disorders
There are a number of different pharmacotherapeutics that can be used to treat cardiovascular disorders. These include:
Diuretics: Diuretics help to remove excess fluid from the body, which can help to lower blood pressure and reduce the workload on the heart.
Beta-blockers: Beta-blockers slow down the heart rate and reduce the force of contraction, which can help to reduce the risk of heart attacks and strokes.
Calcium channel blockers: Calcium channel blockers relax the muscles in the walls of the arteries, which can help to lower blood pressure and improve blood flow.
ACE inhibitors: ACE inhibitors help to relax the blood vessels and reduce the production of angiotensin II, a hormone that can damage the heart and blood vessels.
Angiotensin receptor blockers (ARBs): ARBs work in a similar way to ACE inhibitors, but they do not block the production of angiotensin II.
Statins: Statins are a type of cholesterol-lowering medication that can help to reduce the risk of heart attacks and strokes.
Antiplatelet drugs: Antiplatelet drugs help to prevent the formation of blood clots, which can be a major cause of heart attacks and strokes.
Case Study
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The case study assigned by my instructor for this assignment is about a 65-year-old man with a history of coronary artery disease, hypertension, and high cholesterol. He is currently taking the following medications:
Atenolol (beta-blocker)
Lisinopril (ACE inhibitor)
Simvastatin (statin)
Aspirin (antiplatelet drug)
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Pharmacokinetics and Pharmacodynamics
Pharmacokinetics is the study of how a drug is absorbed, distributed, metabolized, and excreted by the body. Pharmacodynamics is the study of how a drug works on the body.
The factors that can influence a patient's pharmacokinetic and pharmacodynamic processes include:
Genetics: Some people metabolize drugs more slowly or quickly than others, which can affect the amount of drug that is available to the body to work.
Gender: Women tend to metabolize some drugs more slowly than men, which can lead to higher blood levels of these drugs.
Ethnicity: Some ethnic groups are more likely to metabolize drugs in certain ways than others.
Age: Older adults tend to metabolize drugs more slowly than younger adults, which can lead to higher blood levels of these drugs.
Behavior factors: Smoking, drinking alcohol, and using certain medications can all affect the way that drugs are metabolized and work in the body.
Impact of Pharmacokinetic and Pharmacodynamic Changes
Changes in the pharmacokinetic and pharmacodynamic processes can impact a patient's recommended drug therapy in a number of ways. For example, if a patient is taking a drug that is metabolized more slowly than usual, the doctor may need to prescribe a lower dose of the drug to avoid toxicity. If a patient is taking a drug that is not working as well as it used to, the doctor may need to change the dose or type of drug.
Improving Drug Therapy Plan
There are a number of things that can be done to improve a patient's drug therapy plan. These include:
Monitoring the patient's blood levels of drugs to make sure that they are in the therapeutic range.
Adjusting the dose of drugs as needed to maintain therapeutic blood levels.
Changing the type of drug if it is not working as well as it used to.
Educating the patient about their medications and how to take them properly.
Conclusion
Pharmacotherapeutics can play an important role in the treatment of cardiovascular disorders. By understanding the factors that can influence a patient's pharmacokinetic and pharmacodynamic processes, doctors can improve the way that they prescribe and monitor medications
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