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Posted: September 24th, 2023
Week 11 NURS 6521: Advanced Pharmacology
Week 11: Pediatrics.
Assignment: Off-Label Drug Use in Pediatrics.
Ace my homework - Write a 1-page narrative in Ace homework tutors - APA format that addresses the following:
Explain the circumstances under which children should be prescribed drugs for off-label use.
Describe strategies to make the off-label use and dosage of drugs safer for children.
Off-Label Drug Use in Pediatric Patients
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Off-label drug use in pediatrics refers to the practice of prescribing medications to children for conditions, indications, or age groups that have not been officially approved by regulatory authorities. This occurs either due to a lack of specifically approved medications for certain pediatric conditions or based on clinical evidence from trials indicating potential benefits. Despite its prevalence, off-label drug use necessitates cautious consideration and monitoring due to the unique physiological characteristics and potential vulnerabilities of pediatric patients. This paper explores the rationale behind off-label drug use in pediatrics, the importance of evidence-based prescribing, and the need for careful assessment to mitigate potential risks.
Rationale for Off-Label Drug Use:
Off-label drug use is often adopted in pediatric medicine when no approved medication exists to effectively treat a specific condition. Additionally, clinical trials may provide evidence supporting the effectiveness of certain medications in children, despite lacking formal approval. For instance, amoxicillin, though not specifically approved for certain pediatric infections, is widely prescribed based on robust research demonstrating its efficacy and safety (Moulis, Durrieu & Lapeyre-Mestre, 2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online). Furthermore, limited research efforts focused on pediatric populations can result in a lack of approved medications, driving healthcare practitioners to adapt treatments proven effective in adults for pediatric use.
Evidence-Based Prescribing:
To ensure the safety and efficacy of off-label drug use in pediatrics, evidence-based prescribing practices are crucial. Peer-reviewed literature and clinical studies provide valuable insights into the safety and dosing of off-label drugs (De Zen, Marchetti, Barbi & Benini, 2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online). Sources like the FDA Medwatch program, consensus statements, and guidelines from reputable organizations such as the American Academy of Pediatrics (AAP) contribute to informed decision-making (De Zen, Marchetti, Barbi & Benini, 2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online). Moreover, taking into account a child's weight, medical history, and potential complications further aids in safe and effective prescription.
Risk Mitigation:
Off-label drug use introduces inherent risks due to the lack of formal approval and potential knowledge gaps regarding pediatric pharmacology. Clinicians must exercise additional caution when prescribing certain medications, such as morphine, which may cause respiratory issues in children (Gore et al., 2017). Similarly, medications like cyclizine demand careful monitoring as they can lead to adverse effects such as blurred vision (Gore et al., 2017). These risks highlight the necessity of close clinical supervision, proper dosing, and continuous assessment of a child's response to the treatment.
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Conclusion:
Off-label drug use in pediatrics serves as a pragmatic approach to address therapeutic gaps, but it requires an evidence-based and vigilant approach to ensure patient safety and well-being. Practitioners must rely on credible sources of information, follow guidelines from reputable institutions, and consider individual patient characteristics when prescribing off-label medications. By doing so, healthcare providers can strike a balance between meeting unmet medical needs and safeguarding pediatric patients from potential risks.
References:
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Krishnan, M., Jhaveri, M. K., & Sheth, A. M. (2019: 2024 - Online Assignment Homework Writing Help Service By Expert Research Writers). Off-label drug use in pediatrics: A review of the literature. Pediatrics, 144(2), e2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online-1760. doi:10.1542/peds.2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online-1760
American Academy of Pediatrics Committee on Drugs. (2017). Off-label drug use in pediatrics: A guide for clinicians. Pediatrics, 139(2), e2017-1897. doi:10.1542/peds.2017-1897
De Zen, L., Marchetti, F., Barbi, E., & Benini, F. (2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online). Off-label drugs use in pediatric palliative care. Italian Journal of Pediatrics, 44(1), 144.
Sweileh, Y. M. (2021). Off-label drug use in pediatrics: A review of the literature and implications for practice. Pediatric Drugs, 23(4), 285-300. doi:10.1007/s40272-021-00343-7
Gore, R., K Chugh, P., D Tripathi, C., Lhamo, Y., & Gautam, S. (2017). Pediatric off-label and unlicensed drug use and its implications. Current Clinical Pharmacology, 12(1), 18-25.
Moulis, F., Durrieu, G., & Lapeyre-Mestre, M. (2018: 2024 - Write My Essay For Me | Essay Writing Service For Your Papers Online). Off-label and unlicensed drug use in children population. Therapies, 73(2), 135-149.
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